Depression2025-07-10T11:59:31+00:00

Depression and Addiction: St. Louis Dual Diagnosis Treatment

Depression and addiction are common co-occurring disorders, or disorders that occur at the same time. These conditions can interact and impact each other, adding complexity to treatment and recovery. However, at Engage Wellness in St. Louis, we understand the complex interplay between these conditions and take an integrative approach to mental health and addiction treatment.

In addressing both conditions simultaneously, instead of individually, we can address the ways depression and addiction influence each other – and treatment options – to promote lasting recovery.

Key Points

  • Addiction and depression often co-occur, with each influencing and exacerbating the other in a vicious circle.

  • Some common factors that contribute to the development of depression or addiction increase the likelihood of a dual diagnosis.

  • Overlapping symptoms between depression and addiction make it difficult to diagnose and treat these conditions.

  • Dual diagnosis treatment is essential to treat depression and substance use disorder effectively.

What Is Depression?

Depression, or major depressive disorder, is a common and serious mental disorder that negatively affects the way a person feels, thinks, acts, and responds to the world. According to a 2023 national survey, nearly 3 in 10 adults (29%) have been diagnosed with depression at some point in their lives.[1] Depression is more common among women and younger adults, but anyone of any age can experience depression.

The symptoms of depression can vary but may include:[2]

  • Feeling sad, irritable, or hopeless

  • Losing interest in activities once enjoyed

  • Appetite or weight changes

  • Sleep problems
  • Low energy and fatigue

  • Increase in purposeless activity or slowed movements or speech

  • Feeling worthless or guilty

  • Difficulty thinking or concentrating

  • Forgetfulness

  • Suicidal ideation or attempts

It’s important to note that feeling depressed from time to time is common. Depressive disorder is more severe and pervasive, with symptoms that occur most of the day, most days, for longer than two weeks, and symptoms that negatively impact day-to-day life.[3]

There are other types of depression outside of major depressive disorder, including:[4]

  • Seasonal depression: A type of depression that occurs at certain times of year, typically in the fall or winter when the daylight hours are shorter. It often improves in spring and summer.

  • Bipolar depression: The depressive phase of bipolar disorder, characterized by low mood, fatigue, and loss of interest. It alternates with periods of mania or hypomania.

  • Persistent depressive disorder: A long-term form of depression that lasts two years or more. Symptoms are less severe than major depression but more chronic, often including low self-esteem, fatigue, and sadness.

  • Perinatal depression: Depression that occurs during pregnancy or after childbirth (postpartum depression) and includes feelings of sadness, anxiety, and exhaustion that interfere with daily care.

  • Disruptive mood dysregulation disorder (DMDD): A mood disorder in children and adolescents marked by chronic irritability and severe temper outbursts that are out of proportion to the situation.

  • Premenstrual dysphoric disorder: A severe form of premenstrual syndrome (PMS) with intense emotional and physical symptoms like mood swings, irritability, and depression in the weeks before menstruation.

Drug Addiction and Interaction with Depression

Addiction and depression can often occur at the same time, often exacerbating each other. The symptoms of depression may lead people to self-medicate with drugs or alcohol to feel happier, numb emotional pain, or become more comfortable in social situations. Over time, this can lead to drug or alcohol dependence or addiction.

Similarly, a substance use disorder (addiction) can contribute to the development of depressive symptoms by influencing brain chemistry and affecting mood. It becomes more difficult for people engaging in substance abuse to feel pleasure without the use of substances.

In addition, there are some common risk factors and overlapping symptoms that can make it challenging to understand which condition came first and which symptoms are caused by which condition. Treating depression and addiction dual diagnosis requires an integrative approach that addresses each condition and the interplay between them, rather than treating them as singular disorders one at a time.

Causes of Depression and Addiction

Depression is a common disorder, but experts still aren’t sure of the exact causes. There are some contributing factors, however:

  • Brain structure: The brains of people with depressive disorder are structurally different from those who do not have depression. Imaging studies reveal that areas of the brain that are responsible for mood, cognition, sleep, and metabolic function are unique in people with serious mood disorders like depression.[5]
  • Environment: A dysfunctional home or history of physical, sexual, or emotional abuse in childhood can increase the chances of developing depression in adolescence or adulthood.[6] In these cases, trauma-informed care can be useful for processing unresolved pain and healing.
  • Genetics: The neurological differences that distinguish people with depression may have a genetic component. Research suggests that people who have a close relative with depression are 20% to 30% more likely to suffer from depression.[7]
  • Situational factors: Not all painful experiences will result in depression, but severe grief like the loss of a loved one or a contentious divorce could cause a person to experience depression if the emotions are not resolved.

  • Brain chemistry: Neurologists and pharmacologists have researched the possible connections between brain chemistry and depression to find possible treatment options, including imbalances in brain chemicals that regulate emotional states and moods.[8]

Like depression, addiction has several possible contributing factors, including environmental factors like family influence with substances or peer groups, genetics, and certain brain chemistry. People with mental health disorders like depression are also at an increased risk of developing a substance use disorder, and some substances can worsen depression with chronic use.

Statistics About Depression and Substance Use Disorders

Depression and addiction commonly co-occur, adding to the challenges people face in recovery. About half of those who experience a mental illness will also experience a substance use disorder, and vice versa.[9] People with mood disorders, such as major depressive disorder or bipolar disorder, are about twice as likely to struggle with addiction.[10]

Research from the Substance Abuse and Mental Health Services Administration (SAMHSA) reports that about 17 million adults in the U.S. had co-occurring mental health and substance use disorders in 2020.[11] The National Survey on Drug Use and Health (NSDUH) also indicates that 7.7 million adults in the U.S. had both a mental health disorder and addiction in 2018, with depression and addiction being one of the most common.[12]

Dual Diagnosis Addiction and Depression Treatment Centers in St. Louis

Dual diagnosis treatment at Engage Wellness offers multiple levels of care. Each level of care is tailored to the level of support and supervision you need at each stage of recovery.

Treatment plans are individualized, but these are some of the common therapies we use for dual diagnosis treatment:

01

Family therapy for depression and addiction involves loved ones in the recovery process to improve communication, rebuild trust, and address relationship dynamics that may contribute to mental illness.

02

Group therapy for depression and addiction connects recovery peers going through similar challenges to foster peer support, accountability, and shared coping strategies and reinforce healthy social interactions.

03

12-Step groups for depression and addiction with peer-led recovery programs like Alcoholics Anonymous (AA) follow a structured approach to overcoming addiction and managing co-occurring depression.

04

Cognitive behavioral therapy (CBT) for depression and addiction provides a structured, evidence-based approach that helps individuals identify and change negative thought patterns and behaviors.

05

Dialectical behavioral therapy (DBT) for depression and addiction was originally developed to help people with intense emotional responses and teaches skills like mindfulness, emotional regulation, and distress tolerance.

06

Eye movement desensitization and reprocessing (EMDR) therapy is a trauma-focused therapy that helps with processing and healing from distressing memories. EMDR is especially beneficial for people with depression and addiction stemming from unresolved trauma.

07

Holistic treatment for depression and addiction focuses on a whole-person healing approach by integrating therapies like meditation, yoga, nutrition, art therapy, and more, to support emotional wellbeing and relapse prevention.

08

Veterans programs provide tailored treatment for military veterans and their unique challenges, including post-traumatic stress disorder, combat trauma, and reintegration challenges.

Frequently Asked Questions About Depression and Substance Use Treatment in St. Louis

Is Addiction Linked to Depression?2025-06-24T00:22:46+00:00

Depression is common for people struggling with addiction to drugs and alcohol. These two conditions can play off each other, with people seeking substances to self-medicate symptoms of depression or experiencing worsening depression symptoms due to the effects of substance use.

How Long Does Dual Diagnosis Treatment Last?2025-06-24T00:23:58+00:00

The duration of dual diagnosis treatment depends on the severity of your conditions and your treatment progress. Generally, treatment lasts a few months, but it can be a year or more in some cases.

Does Depression Ever Go Away Fully?2025-06-24T00:23:41+00:00

Neither depression nor addiction can be truly “cured.” However, effective treatment can help people struggling with co-occurring disorders manage their symptoms, maintain sobriety, and enjoy a healthier life.

[1,2,3,4] What is depression?. Psychiatry.org – What Is Depression? (n.d.). Retrieved from https://www.psychiatry.org/patients-families/depression/what-is-depression on 2025, April 22.

[5] U.S. Department of Health and Human Services. (n.d.-a). Depression. National Institute of Mental Health. Retrieved from https://www.nimh.nih.gov/health/topics/depression on 2025, April 22.

[6] Negele, A., Kaufhold, J., Kallenbach, L., & Leuzinger-Bohleber, M. (2015). Childhood trauma and its relation to chronic depression in adulthood. Depression research and treatment. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC4677006/ on 2025, April 22.

[7] Genetics of Brain Function. (n.d.). Major Depression and Genetics. Retrieved from https://med.stanford.edu/depressiongenetics/mddandgenes.html on 2025, April 22.

[8] What causes depression?. Harvard Health. (2022, January 10). Retrieved from https://www.health.harvard.edu/mind-and-mood/what-causes-depression on 2025, April 22.

[9] U.S. National Library of Medicine. (n.d.). Common comorbidities with Substance Use Disorders Research Report. National Center for Biotechnology Information. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK571451/ on 2025, April 22.

[10] Mental illness and addiction: Facts and statistics. CAMH. (n.d.). Retrieved from https://www.camh.ca/en/driving-change/the-crisis-is-real/mental-health-statistics on 2025, April 22.

[11] 2020 National Survey on Drug Use and Health (NSDUH) releases. SAMHSA.gov. (n.d.). Retrieved from https://www.samhsa.gov/data/data-we-collect/nsduh-national-survey-drug-use-and-health/national-releases/2020 on 2025, April 22.

[12] SAMHSA, C. for B. H. S. and Q. (n.d.-b). Key substance use and mental health indicators in the United States:results from the 2019 National Survey on Drug Use and health. Key Substance Use and Mental Health Indicators in the United States: Results from the 2019 National Survey on Drug Use and Health. Retrieved from https://www.samhsa.gov/data/sites/default/files/reports/rpt29393/2019NSDUHFFRPDFWHTML/2019NSDUHFFR090120.htm on 2025, April 22.

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